A patient requires a 3-dose series of HPV vaccine. What is the condition that necessitates this for those aged 15 and older?

The condition that necessitates a 3-dose series of the HPV vaccine for those aged 15 and older is primarily related to the age at which the series is initiated. For individuals aged 15 years and older, the recommendation is to receive a 3-dose series of HPV vaccine. This is important because the immune response varies depending on age.

For individuals who start the vaccination series at age 15 or older, the dosing schedule includes doses given at 0, 1-2 months, and 6 months after the initial dose. The 3-dose series is critical to ensure effective immunity against the types of HPV targeted by the vaccine.

In contrast, those who start the series before their 15th birthday may only require two doses if the series is started at ages 11 or 12, as younger individuals generally develop a more robust immune response with fewer doses.

This distinction underlines the importance of adhering to the vaccination schedule based on age. The other options relate to specific circumstances that may influence vaccination, but they do not directly change the necessity of the 3-dose series for individuals aged 15 and older who have not started the series.