If two live vaccines are not given simultaneously, what is the required minimum interval between them?

The requirement for a minimum interval of 28 days between two live vaccines is established to ensure the effectiveness of the vaccination schedule. When two live vaccines are administered, the immune response to one vaccine may interfere with the response to the other if they are given too closely together. This can result in reduced immunity from one or both vaccines.

Therefore, allowing a minimum interval of 28 days ensures that the body has sufficient time to mount an appropriate immune response to the first vaccine before the second live vaccine is introduced. This interval helps prevent any potential interference in the immune response and maximizes the effectiveness of both vaccinations.

This guideline is in accordance with recommendations from public health organizations and is vital for ensuring individuals develop adequate immunity to the diseases that the vaccines are designed to prevent.